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KMID : 0377619920570040231
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Korean Jungang Medical Journal
1992 Volume.57 No. 4 p.231 ~ p.235
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Transdermal Estrogen Replacement Therapy in Postmenopausal Women
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Abstract
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To evaluate the clinical effects of transdermal estrogen replacement therapy in postmenopausal women, especially cardiovascular effect by change of serum lipid profiles after the treatment, 32 postmenopausal women - 18 natural menopausal women, 14 women with premature ovarian failure - were studied before and after 6 8 weeks of treatment withE2 containing transdermal therapeutic systems.
1. The postmenopausal symptoms were improved or disappeared in all cases.
2. Significant changes of serum LDL level, HDL/LDL ratio were noted.
3. The side effects of transdermal estrogen replacement therapy were noted with skin eruption (7 cases), vaginal spotting (3 cases) and breast pain (2 cases), but no discontinuation of the treatment was resulted.
This study was concluded that the transdermal estrogen replacement therapy was effective on the prevention of cardiovascular diseases in postmenopausal women.
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